Journal article
Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea
LJ Robinson, MC D'Ombrain, DI Stanisic, J Taraika, N Bernard, JS Richards, JG Beeson, L Tavul, P Michon, I Mueller, L Schofield
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2009
DOI: 10.1128/IAI.00211-09
Abstract
The role of early to intermediate Plasmodium falciparum-induced cellular responses in the development of clinical immunity to malaria is not well understood, and such responses have been proposed to contribute to both immunity and risk of clinical malaria episodes. To investigate whether P. falciparum-induced cellular responses are able to function as predictive correlates of parasitological and clinical outcomes, we conducted a prospective cohort study of children (5 to 14 years of age) residing in a region of Papua New Guinea where malaria is endemic Live, intact P. falciparum-infected red blood cells were applied to isolated peripheral blood mononuclear cells obtained at baseline. Cellula..
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Grants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council of Australia ( grants 516735 and 406601 to L. Schofield; postgraduate research fellowships to L. J. Robinson [356276] and M. C. D'Ombrain [305551]). L. Schofield is an International Research Scholar of the Howard Hughes Medical Institute.